Heart failure (HF) is a major public health issue in both developed and developing countries 1. In the last few decades, advances in drug therapy, implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy – in the earlier phases - as well as mechanical circulatory support with left ventricular assist devices (LVAD) and heart transplantation – when clinical conditions become advanced and recalcitrant - have contributed to improvements in the prognosis of patients with HF and reduced ejection fraction (HFrEF) 1
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