Near-infrared spectroscopy
Addendum: Prospect II & Prospect Absorb trials
Published on March 9, 2021
A report from Piera Capranzano, Rodney De Palma
The PROSPECT II natural history study aimed to assess the relationship between high-risk characteristics of untreated non-culprit lesions (NCLs) and long-term clinical outcomes. Among patients (n=898) with recent myocardial infarction (MI) NCLs were prospectively identified by intravascular ultrasound (IVUS) and their lipid content was assessed by near-infrared spectroscopy (NIRS). The intravascular imaging assessment was performed in the proximal 6-10 cm of the three coronary arteries after successful treatment of all flow-limiting lesions with contemporary drug-eluting stents. Main results of the PROSPECT II study can be summarized as follows1.
At a median follow-up of 3.7 years, the rate of major adverse cardiovascular events (MACE, cardiac death, MI, unstable angina, or progressive angina) related to untreated NCLs was 8% vs. 4.6% of recurrent events related to treated culprit lesions. NIRS identified lipid-rich plaques that were responsible for future coronary events. In the multivariable analysis, plaque burden more than 70% and lipid core burden index (LCBI) >324 were independent predictors of MACE. The combination of lipid-rich plaque (LCBI >324) and large plaque burden identified vulnerable plaques that...Sign up for free!
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