Transcatheter aortic valve implantation

Updated on May 14, 2021
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Addendum on mode of interventions for aortic stenosis: 2021 ESC/EACTS guidelines indications

Published on November 19, 2021


Surgical aortic valve replacement (SAVR) established in the 1960s has been the only definitive treatment for patients with aortic stenosis (AS) for more than four decades11. Effler DB, Favaloro R, Groves LK. Heart Valve Replacement. Clinical Experience. Ann Thorac Surg. 1965;1:4-24. Link. In 1986, Cribier and colleagues introduced balloon aortic valvuloplasty (BAV) as an alternative treatment for inoperable patients with severe AS22. Cribier A, Savin T, Saoudi N, Rocha P, Berland J, Letac B. Percutaneous transluminal valvuloplasty of acquired aortic stenosis in elderly patients: an alternative to valve replacement. Lancet. 1986;1(8472):63-7. Link. Although BAV achieved favourable acute hemodynamic outcomes, restenosis and clinical deterioration occur in most cases within 6-12 months and repeat procedures are frequently needed33. Litvack F, Jakubowski AT, Buchbinder NA, Eigler N. Lack of sustained clinical improvement in an elderly population after percutaneous aortic valvuloplasty. Am J Cardiol. 1988;62(4):270-5. Link. To address the limitation, the concept of transcatheter heart valve (THV) where a bioprosthetic valve was sewn into a stenting scaffold has been developed and repeatedly tested in animal...

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