Objective
to evaluate 6-year clinical and haemodynamic outcomes with TAVI vs surgery in low-risk patients with severe aortic stenosis
Study
international, multicentre, open-label, randomised controlled trial
Population
patients with severe tri-leaflet aortic valve stenosis, a low predicted risk of death (<3%) following surgical aortic valve replacement as assessed by a local multidisciplinary heart team, and anatomical suitability for both TAVI and surgery
Endpoints
6-year rates of all-cause mortality or disabling stroke; 6- and 7-year reintervention
Conclusion
At 6 years, patients who were treated with TAVI or SAVR had comparable rates of all-cause mortality or disabling stroke. At 6 and 7 years, the TAVI arm had a higher reintervention rate compared to SAVR, due to an increased incidence of aortic regurgitation.
Forrest et al. J Am Coll Cardiol. 2026 Feb 16.