Randomised clinical trials in interventional cardiovascular medicine

The PCR Trials Book provides updates on the latest randomised clinical trials of relevance to practising interventional cardiologists, in the field of coronary, valvular and structural interventions. Each trial, selected by the Editors, has been synthesised in order to provide you with a concise overview.

Browse the full content in the Table of Contents to stay informed about the most relevant findings in the field.

The selected medical journals for screening include: New England Journal of Medicine, Lancet, JAMA, BMJ, European Heart Journal, Journal of the American College of Cardiology, Circulation, Annals of Internal Medicine, EuroIntervention, JACC Cardiovascular Interventions, Circulation Cardiovascular Interventions and JAMA Cardiology.

Editors: Robert A. Byrne and Simon Redwood.

Released thanks to the support of CVRI Dublin.

Recent updates (April 22, 2026)

1. Drug-eluting and bare metal stents

1.1 - Comparisons drug-eluting stents

1. Drug-eluting stents

1.2 - Stent comparison in STEMI

2. Stents for left main stem and bifurcation lesions

2.1 - Stents for left main and bifurcation lesions

3. Bioresorbable vascular scaffolds

3.1 - Bioresorbable vascular scaffolds

4. Drug-coated balloons

4.1 - Drug-coated balloons

5. Miscellaneous trials in coronary intervention

5.1 - Vascular access

5.2 - Other

6. Myocardial revascularisation strategy

6.1 - PCI vs CABG

6.2 - Revascularisation vs medical

6.3 - Miscellaneous

7. Revascularisation in ACS

7.1 - Fibrinolysis vs PCI

7.2 - Management of multivessel disease

7.3 - Revascularisation strategy

8. Intravascular imaging-guided PCI

8.1 - IVUS-guided PCI

8.2 - OCT-guided PCI

9. Lesion haemodynamic assessment and PCI

9.1 - Lesion haemodynamic assessment and PCI

10. Antithrombotic therapies

10.1 - Dual antiplatelet treatment

10.2 - Antiplatelet therapy in OAC

10.3 - Long-term antiplatelet treatment

10.4 - Anticoagulation during PCI

11. Cardiogenic shock and cardiac arrest

11.1 - Mechanical circulatory support

11.2 - Coronary angiography after cardiac arrest

11.3 - Cardiac arrest center strategy

12. Percutaneous intervention for aortic valve stenosis

12.1 - TAVI vs surgery

12.2 - TAVI vs surveillance

12.3 - Comparisons of TAVI devices

12.4 - TAVI-antithrombotic therapy

12.5 - Cerebral protection

12.6 - Vascular closure

12.7 - PCI and TAVI

12.8 - Miscellaneous

13. Percutaneous intervention for mitral/tricuspid valve and PFO/LAA closure

13.1 - Mitral valve interventions

13.2 - Tricuspid valve interventions

13.3 - LAA closure

13.4 - PFO closure/ASD closure

14. Renal denervation

14.1 - Renal denervation

15. Peripheral

15.1 - Percutaneous treatment of peripheral artery disease

16. Pulmonary interventions

16.1 - Pulmonary artery denervation

16.2 - Interventions for pulmonary embolism

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