11. Antithrombotic therapies

6-month vs 12-month or longer DAPT in ACS

SMART-DATE
Objective
to investigate whether a reduced 6-month duration of DAPT would be non-inferior to the conventional 12-month or longer duration of DAPT in patients with ACS
Study
multicentre, open-label non-inferiority randomised trial (margin 2.0%)
Population
patients with unstable angina, non-STEMI and STEMI
Endpoints
patients with unstable angina, non-STEMI and STEMI
Conclusion
prolonged DAPT in patients with ACS should remain standard of care
Hahn et al. Lancet. 2018;391:1274-84
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