Objective
to determine whether angiography-based vessel FFR (vFFR)guided revascularisation is non-inferior to pressure-wire FFRguided revascularisation for 1-year death, MI, or revascularisation in patients with intermediate coronary lesions
Study
international, multicentre, open-label, randomised, non-inferiority trial
Population
patients with chronic or acute coronary syndromes and at least one 3080% intermediate lesion in a 2.5 mm native epicardial vessel suitable for both vFFR and wire-based FFR assessment
Endpoints
composite of death from any cause, any myocardial infarction, or any revascularisation at 1 year
Conclusion
In patients with intermediate coronary lesions, revascularisation guided by vFFR was noninferior to FFR-guided revascularisation in terms of a composite of death, myocardial infarction, or revascularisation at 1 year.
Daemen et al. N Engl J Med. 2026 Mar 29.