10. Lesion haemodynamic assessment and PCI

Angiography-derived FFR vs IVUS to guide PCI

FLAVOUR II
Objective
to assess the 12-month clinical outcomes of angiography-derived FFR or optimisation of stent implantation for PCI treatment of coronary stenosis
Study
investigator-initiated multicentre randomised non-inferiority trial
Population
patients with ischaemic heart disease and at least one 50% coronary stenosis
Endpoints
composite of death, MI or revascularisation at 12 months
Conclusion
An angiography-derived, FFR-guided PCI strategy was non-inferior to IVUS guidance.
Hu et al. Lancet. 2025 Mar 28:S0140-6736(25)00504-5.
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