Objective
to study the efficacy of inorganic nitrate to prevent contrast-induced nephropathy (CIN) in patients undergoing coronary angiography for ACS
Study
double-blind, single-center placebo controlled radomised trial
Population
patients with NSTE-ACS at risk of CIN (eGFR<60mL/min or clinically at risk of CIN)
Endpoints
incidence of CIN (≥ 0.3 mg/dL or ≥ 26.5 μmol/L increase in creatinine within 48h or 1.5x within 1 week after coronary angiography
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Conclusion
among patients at risk of renal injury undergoing coronary angiography for ACS inorganic nitrate reduced CIN compared to placebo