Objective
to study the safety and effectiveness of intensified antiplatelet therapies double dose clopidogrel (DOUBLE) vs. DOUBLE plus cilostazol (TRIPLE) vs. conventional clopidogrel (STANDARD) after PCI
Study
single centre, randomised controlled trial
Population
patients with low responsiveness to clopidogrel measured with thrombo elastography
Endpoints
MACCE as composite of all-cause death, MI,TVR or stroke at 18 months
Conclusion
in patients with low responsiveness to clopidogrel a double dose of clopidogrel plus cilostazol improved clinical outcomes without increasing major bleeding rates
Tang et al. Circulation. 2018;137:2231-45