Objective
to report the clinical outcomes of early aortic valve intervention versus guideline-directed conservative therapy for the treatment of aortic valve stenosis
Study
prospective open-label multicentre randomised trial
Population
patients with asymptomatic severe aortic stenosis and myocardial fibrosis (assessed by cardiac MRI); early aortic intervention: surgery 55%, TAVI 45%
Endpoints
composite of all-cause death or unplanned aortic-related hospitalisation in a time-to-first-event analysis
Conclusion
Early aortic intervention in asymptomatic patients with severe aortic stenosis and myocardial fibrosis has no demonstrable effect on adverse events as compared to conservative treatment.
Loganath et al. JAMA. 2025;333(3):213-221.