Objective
to compare the clinical outcomes of PFO closure with medical treatment in patients with cryptogenic stroke and high risk PFO
Study
multicentre, open-label randomised superiority trial
Population
patients with high-risk PFO: atrical septum aneurysm, hypermobility or PFO size â¥2 mm
Endpoints
composite of stroke, vascular death or major bleeding (TIMI) during 2 years follow-up
Conclusion
PFO-closure in patients with high-risk PFO was associated with a lower rate of adverse events compared to medication only
Lee et al. J Am Coll Cardiol. 2018;71:2335-42