Objective
to assess the clinical efficacy of left atrial appendage closure compared to oral anticoagulation in patients who had undergone ablation for atrial fibrillation (AF)
Study
international, multicentre, randomised study
Population
patients with AF with CHADS-VASc score 2 in men and 3 in women
Endpoints
1) non-procedure-related major bleeding or clinically relevant bleeding or 2) composite of death, stroke or systemic embolism at 36 months
Conclusion
among patients who underwent atrial fibrillation ablation, left atrial appendage closure was associated with lesser bleeding complications and lesser major adverse events at 36 months compared to oral anticoagulation
Wazni et al. NEJM 2024; 391:online November 16