Objective
to determine whether elective left ventricular unloading with a percutaneous microaxial flow pump during complex high-risk PCI reduces major adverse clinical outcomes compared with PCI without planned mechanical circulatory support in patients with severe LV dysfunction and extensive CAD
Study
prospective, multicentre, open-label, randomised controlled trial
Population
patients with severe left ventricular dysfunction and extensive coronary artery disease undergoing planned complex PCI
Endpoints
composite of all-cause death, disabling stroke, spontaneous MI, hospitalisation for cardiovascular causes, or periprocedural myocardial injury at 12 months
Conclusion
In patients with severely impaired left ventricular function who underwent complex PCI, elective left ventricular unloading with a microaxial flow pump was not found to reduce the risk of major adverse clinical outcomes at 1 year.
Perera et al. N Engl J Med. 2026 Mar 29.