Objective
to prospectively compare orbital atherectomy with a balloon angioplasty-based strategy before stent implantation for the treatment of severely calcified coronary lesions
Study
multicentre, open-label, randomised controlled trial in USA
Population
patients with severely calcified lesions that could be treated with either orbital atherectomy or balloon angioplasty before stent implantation
Endpoints
target vessel failure at 1 year and post-procedural minimal stent area on OCT at the site of maximal calcification
Conclusion
The routine use of orbital atherectomy did not improve MSA or reduce TVF at 1 year compared with balloon angioplasty for the preparation of severely calcified coronary lesions prior to DES implantation.
Kirtane et al. Lancet. 2025:S0140-6736(25)00450-7.