10. Lesion haemodynamic assessment and PCI

PCI guided FFR

FAME 2 5 years
Objective
to report the 5-year clinical outcomes of FFR guided PCI and medical treatment in patients with stable CAD compared to an initial medical treatment
Study
multicentre randomised trial
Population
patients with stable angina or documented silent ischemia and a haemodynamically significant stenosis (FFR ≤0.80)
Endpoints
composite of death, MI or urgent revascularisation
Conclusion
an initial PCI-guided treatment was associated with a lower 5-year adverse event rate compared to an initial medical treatment in patients with stable CAD. The difference was mainly caused by increase in urgent revascularisation rate in the medical treatment group.
Xaplanteris et al. NEJM. 2018;379:250-9
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