Objective
to determine whether TAVI is non-inferior to surgery in patients at moderately increased operative risk
Study
investigator, pragmatic multicentre (UK), randomised non-inferiority trial (margin: <5% absolute difference in mortality
Population
patients aged 70 years or older with severe symptomatic aortic stenosis and increased operative risk due to co-morbidity or age (or aged >80 years alone) (Society of Thoracic Surgeons mortality risk score was 2.6% (mean))
Endpoints
all-cause mortality at 1-year
Conclusion
TAVI was non-inferior to surgery among patients aged 70 years or older with severe symptomatic aortic stenosis and moderately increased operative risk
UK TAVI investigators. JAMA. 2022;327:1875-87