Objective
to assess the clinical outcomes of early intervention with TAVR as compared to routine clinical surveillance every 6 to 12 months for the treatment of asymptomatic aortic stenosis
Study
prospective, multicentre, open-label randomised trial
Population
patients with severe asymptomatic aortic stenosis and LVEF >50%
Endpoints
composite of death, stroke or unplanned hospitalisation for cardiovascular causes
Conclusion
a strategy of early TAVR was superior to routine clinical surveillance for the treatment of asymptomatic severe aortic stenosis
Généreux et al. NEJM. 2024 28 Oct.