11. Antithrombotic therapies

Ticagrelor plus aspirin for 1 month, followed by ticagrelor alone for 23 months compared to 12 months standard DAPT followed by 12 months aspirin alone

GLOBAL LEADERS
Objective
to report the clinical 2-year outcome of a combination of ticagrelor and aspirin for 1 month, followed by ticagrelor for 23 months compared to standard DAPT for 12 months (aspirin plus clopidogrel or ticagrelor) followed by another 12 months aspirin alone
Study
randomised, open-label, multicentre superiority trial
Population
patients with stable CAD or ACS
Endpoints
composite of all-cause death or new Qwave MI at 24 months; secondary safety endpoint: bleeding BARC grade 3 to 5
Conclusion
treatment with ticagrelor plus aspirin (1 month) followed by ticagrelor for 23 months was not superior to standard DAPT (12 months) followed by another 12 months of aspirin treatment
Vrankx et al. Lancet. 2018;392:940-9
follow us
Copyright © 2025 Europa Group – All rights reserved.
The content of this site is intended for health care professionals.