Objective
to study the efficacy and safety of ultrasound renal denervation compared to sham procedure for the treatment of hypertension without confounding influence of antihypertensive medication
Study
multicentre, sham-controlled, randomised trial
Population
patients with uncontrolled hypertension SBP/DBP ⥠140/90 mm Hg but < 180/120 mm Hg and eFR 40 mL/min/1.73 m2 or greater
Endpoints
mean change is daytime ambulatory SBP at 2 months
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Conclusion
ultrasound renal denervation reduced daytime ambulatory SBP at 2 months compared to sham-procedure
Azizi et al JAMA: 2023; 329: 651-661